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Biomedical Research

The functionality of nearly any biomedical system can be traced down to an intricate and complex system of interacting molecules, operating under chemical and physical principles, that ultimately drives biological phenomena, from the microscale to the macroscale. And this is the approach that we take as we seek to develop solutions to relevant issues in modern medicine that have not yet been fully resolved - protein folding disorders, pathogen antibiotic resistance, enzymatic catalysis, just to name a few. Our research collaborations are driven by these pressing questions in molecular and cell biology, and are tackled from both computational and empirical grounds. We see tremendous potential in the parallel usage of tools from biochemistry/structural biology, computational modeling, and organic chemistry in developing new knowledge of the molecular systems that drive human health. We seek aspiring biomedical researchers who are unafraid to tackle intellectually challenging problems with enthusiasm, curiosity, and creativity to push forwards the limits of molecular medicine. We hope you will join us this summer in #ASDRP2019.

Student Researchers| Summer 2019

Amyloid Inhibitors of Aβ-42 Towards Developing Therapeutic Strategies for Alzheimer's Disease

Aggregation of the peptide Aβ-42 has been linked to progression of Alzheimer's disease. We are interested in natural product screening and nature-inspired synthetic compounds that inhibit aggregation of amyloid fibrils. Further, we employ various computational methods to understand the biophysical parameters behind amyloid formation. 

Structure-Activity Relationships in Small Molecule Antibiotic Compound Development

Sulfa antibiotics have been previously shown to be competitive inhibitors of dihydropteroate synthase (DHPS), which is integral in the biosynthetic pathway of folic acid in many prokaryotes. Here, we investigate structure-activity relationships in a synthetic library of novel small molecules in antimicrobial activity. 

Molecular Oncology: Pharmacophores in Tubulin-Binding Antiproliferative Agents

Several natural product  have been shown to attenuate the growth of tumor cells by blocking mechanisms of the mitotic spindle in rapidly dividing cells. Here, we incorporate natural product screening and de novo molecular design to engineer the next generation of potentially antiproliferative agents towards anti-cancer drugs. 

Total Synthesis of Etoposide and Anti-Tumor Activity of Etoposide Analogs

Etoposide is a clinically used drug that treats a variety of cancer types by inhibiting the action of topoisomerase during DNA replication. Here, we describe a synthetic route towards etoposide, and the design and development of etoposide analogs as potential anti-cancer pharmaceuticals.  

What We Do

Biomedical research is interdisciplinary - we are huge fans of combining the best techniques and approaches across biochemistry, organic chemistry, and molecular biology towards understanding some of the most pressing issues in molecular medicine today. 

Information & Leadership

Ankur Gupta
Director of Biomedical Research
ankur.gupta@fremontstem.com
Harman Brah
Deputy Director of Biomedical Research
harman.brah@fremontstem.com
Research Students | Summer 2019
A. Dong | H. Yallampali | I. Yeleswarapu | R. Jain | S. Sista | A. Siva
K. Huang | J. Wu | A. Gowda | A. Shah | T. Vaidya | S. Yelugoti
S. Narang | T. Jain | V. Rajaram | W. Chang | K. Chattopadhyay
B. Fu | A. Boominathan | A. Batada | Y. Rasheed | A. Kesanapally
I. Kolluru | A. Morumganti | H. Rajan
Group Meetings: FRIDAYS @ 8:30 PM - 10:00 PM
Ankur Gupta
Program Director
Edward Njoo
Organic Chemistry

Advisors

The Biomedical Research Cluster at ASDRP is co-advised by a group of advisors across a diversity of scientific fields. 

Lauren Hui
Molecular Biology
Harman Brah
Biochemistry

Computation & Theory

Fluoresence Spectroscopy

Targeted Small Molecule Synthesis

In Vivo Cell Studies

Molecular Dynamics

Natural Product Screening